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Remodeling lipid metabolism, particularly the redistribution of oxidizable PUFAs, leads to increased lipid peroxidation and induces ferroptosis in tumors [17]

TNF-alpha showed potential in reducing tissue IR, improving glucose homeostasis, and preventing T2DM onset in animal models

There remains much to learn about the roles, regulation, and therapeutic intervention of GPX4

[6] Semaglutide for the treatment of obesity or weight management should not be used during pregnancy because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm due to the potential hazard of maternal weight loss to the fetus

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